OroGen Plus and A Cell in HairThere have been many questions by patients regarding the difference between A Cell’s extracellular matrix ( ECM) and OroGen Plus (ECM) so this is an explanation and our reasoning behind using a natural protein matrix for hair regeneration.

Fig 1, below left, demonstrates that the ECM in OroGen Plus is derived from your own plasma proteins (fibrin, fibrinectin and vitronnectin). When the plasma is concentrated the proteins become highly concentrated and form a bio-scaffold.

Fig 2, below right, is a scanning electron microscope view of the OroGen Plus ECM after “your own concentrated proteins are mixed with your own growth factors to form this ECM”.

OroGen Plus “Extra Cellular Matrix” Made from your own “Natural Proteins”

OroGen Plus and A Cell in Hair OroGen Plus and A Cell in Hair Fig 1                                                                                                       Fig 2

The benefits of this complex is that “your” growth factors are entrapped inside “your” protein (ECM). This complex then “calls” or “signals” other cells to migrate to the bio-scaffold where these new cells can attach and then proliferate or spread. When this happens tissue regenerates.

Since hair is made from your own protein…. “does it make sence that regenerating hair from your own protein and growth factors”, which OroGen Plus has demonstrated in Androgenic Alopecia (Male Pattern), Alopecia Areata and Discoid Lupus is a reasonable and safe way?

A Cell “Extra Cellular Matrix” Made from Pig Bladder

OroGen Plus and A Cell in HairOroGen Plus and A Cell in Hair Fig 3                                                                            Fig 4

A Cell is an acellular ( no cells) ECM made from the lining of a pigs bladder ( Fig 3). A Cell extracellular matrix ECM, (Fig 4, above right) is comprised of a “combination of multiple growth factors and multiple types of collagen known to promote tissue regeneration while reducing scarring and pain associated with inflammation so it does have benefit in donor sites in hair transplantation”.

A Cell on its own has not demonstrated hair regeneration; however, in combination with PRP reversal of thinning hair has been shown so the question is, “was it the PRP or A Cell that had the effect on hair growth”?

The best way to evaluate a patient is to arrange a personal, in-depth consultation. However, this is impossible for many patients who fly in from other parts of the country or world. For this reason we have developed the remote consultation package, which is an acceptable alternative to the in-person personal consult.

Once your photos and questionnaire are reviewed, we will telephone you to discuss your questions or concerns regarding the procedure. You will also be given a suggested treatment plan and the costs involved. Click here for more complete infomation on our free on-line hair restoration consultation process.

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